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Frequency patterns of T-cell exposed motifs in immunoglobulin heavy chain peptides presented by MHCs

Frequency patterns of T-cell exposed motifs in immunoglobulin heavy chain peptides presented by MHCs

July 13, 2025 Category: Blog

Immunoglobulins are highly diverse protein sequences that are processed and presented to T-cells by B-cells and other antigen presenting cells.We examined a large dataset of immunoglobulin heavy chain variable regions (IGHV) to assess the diversity of T-cell exposed motifs (TCEM).TCEM comprise those amino acids in a MHC-bound peptide which face out

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Emollient formulations containing antiseptics reduce effectively the level of Staphylococcus aureus on skin

July 13, 2025 Category: Blog

Fabrizio Spada, Tanya M Barnes, Kerryn A Greive Research & Development, Ego Pharmaceuticals, Braeside, Victoria, AustraliaCorrespondence: 30" Double Wall Oven Fabrizio SpadaEgo Pharmaceuticals Pty Ltd, 21-31 Malcolm Road, Braeside, Victoria 3195, AustraliaTel +61 39 586 8874Fax +61 39 580 7647Email [email protected]: Increas

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Entanglement dynamics in dispersive optomechanics: Nonclassicality and revival

July 13, 2025 Category: Blog

We study entanglement dynamics in a dispersive optomechanical system consisting of two optical modes and a mechanical oscillator inside an optical cavity.The one eared bridles two optical modes interact with the mechanical oscillator, but not directly with each other.The appearance of optical entanglement witnesses nonclassicality of the oscillator

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An industrial evaluation of proteochemometric modelling: Predicting drug-target affinities for kinases

July 13, 2025 Category: Blog

Deep learning proteochemometric (PCM) models have been reported to achieve excellent performances on public benchmarking datasets.Nevertheless, numerous papers have cast doubt on commonly used evaluation metrics, suggesting they do not reflect true prospective predictive abilities.The aim of this study is to provide a comprehensive assessment of pe

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Pressure - Settlement Characteristics of Shallow Foundations using Finite Element Method

July 13, 2025 Category: Blog

The present study attempts to represent the behavior of shallow foundations under the effectof eccentric inclined loading in terms of the main criteria of design which are the ultimate bearingcapacity, permissible settlement, horizontal displacement and tilt.Due to the square shape of the analysed foundations, three dimensional finite element analy

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